The Malankara Orthodox Church is an ancient Church of India and it traces its origin to as far back as A. D. 52 when St. Thomas, one of the twelve Apostles of Jesus Christ, on his evangelical mission to the Cochin Jews, established Christianity in the South Western parts of the sub-continent. St. Thomas was martyred in A.D. 72 at Mylapore, Chennai and his tomb is a national monument in India. 

St Mary's Orthodox Church of St Louis is registered as a parish under the South West American Diocese of the Malankara Orthodox Church. Founded in the year 1990 with just seven families and a rented place to worship, St. Marys Church in St. Louis has now grown to a strength of 30 families with its own Church building and Cemetery.

With the grace of God, the parish strives to nourish its members with inspiring and prayerful liturgy in the spirit of Orthodox Faith. We hope to reach out to others in Christian love, and by the witness of our lives and the service of our members, attract others to Jesus Christ and Orthodox Faith. On January 2nd, 2010, Dn. Mathew K Alexander from St. Mary's Orthodox church, St. Louis was ordained to Priesthood at this church. Diocesan Bishop, His Grace Alexios Mar Eusebius was the chief celebrant and was assisted by His Grace Zachariah Mar Nicholovos.